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Can the Origin of the Genetic Code Be Explained by Direct RNA Templating?


 
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1. Title Title of document Can the Origin of the Genetic Code Be Explained by Direct RNA Templating?
 
2. Creator Author's name, affiliation, country Stephen C. Meyer; Discovery Institute; United States
 
2. Creator Author's name, affiliation, country Paul A. Nelson; Biola University; United States
 
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4. Description Abstract Motivated by the RNA world hypothesis, Michael Yarus and colleagues have proposed a model for the origin of the ‘universal’ genetic code, in which RNA aptamers directly template amino acids for protein assembly. Yarus et al. claim that this “direct RNA templating” (DRT) model provides a stereochemical basis for the origin of the code, as shown by the higher-than-expected frequency of cognate coding triplets in aptamer amino acid-binding sites. However, the DRT model suffers from several defects. These include the selective use of data, incorrect null models, a weak signal even from positive results, an implausible geometry for the primordial RNA template (in relation to the universally-conserved structures of modern ribosomes), and unsupported assumptions about the pre-biotic availability of amino acids. Although Yarus et al. claim that the DRT model undermines an intelligent design explanation for the origin of the genetic code, the model’s many shortcomings in fact illustrate the insufficiency of undirected chemistry to construct the semantic system represented by the code we see today.
 
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7. Date (YYYY-MM-DD) 2011-08-24
 
8. Type Status & genre Peer-reviewed Critical Review
 
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9. Format File format PDF
 
10. Identifier Universal Resource Indicator https://bio-complexity.org/ojs/index.php/main/article/view/BIO-C.2011.2
 
10. Identifier Digital Object Identifier 10.5048/BIO-C.2011.2
 
11. Source Journal/conference title; vol., no. (year) BIO-Complexity; Vol 2011
 
12. Language English=en en
 
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